A lot of Forum members experience problems with sync'ing with iTunes. One member has a tag line - "Think before you sync or you may sink" and that about sums it up. Several people have questioned the need to continually sync with your PC. My iPad was connected to my PC the day I bought it and I've never connected it again since.
OK - suppose my iPad goes down and I have to restore it to its original factory settings. The iTunes store has details of all the apps, videos and music that I've bought and I can simply download them again at no cost.
The only thing I'd loose would be documents that I'd authored on the iPad. So I use the Apple MobileMe iDisk cloud server that allows me to upload documents, photos, contacts and calendars between the iPad and my PC over WiFi or 3G - no iTunes in sight.....
Tim
Scotland