It WILL be pressed against the screen of the iPad when it's closed, so do be aware of that. If you have Ghost Armor or Invisible Sheild, anything in the card holders will leave a temporary (and annoying) impression on the screen surface. Even the sewn seam of the pocket that runs the width of the cover leaves an impression on mine. I remedied it by keeping my microfiber cloth (for cleaning the screen) sandwiched between screen and cover when I have it closed. I'm not sure how it would affect the screen itself without any kind of shield on it, but it could possibly be a concern.
Keep a cloth handy as I suggested above and you'll be fine. I'm very happy with my Sena.