Generally, safe mode is your iPad"s way of saying something you installed didn't agree with it. Think of the last tweak(s) you just installed from Cydia. Then, go back to Cydia and either uninstall them one by one or all at once. After the uninstall, reboot and see if that fixes it.
Then, you can go back to Cydia and reinstall the tweaks you deleted, one at a time - reboot after each one to find the guilty party.
If you still have trouble, give us the list of tweak(s) you installed just before you started with the safe mode troubles. Maybe one of us can find the guilty culprit...
Good luck.
Marilyn