Not all tweaks work on iOS 5, see this thread:
http://www.ipadforums.net/jailbreak-applications-tweaks/25824-ultimate-list-jailbreak-tweaks.html The ones in blue are confirmed to work in iOS 5. I think that is the only hindrance you face, you don't have the blobs for 4.3.3 so should you ever need to restore you lose your JB. With iOS 5 you can't downgrade to a previous version of iOS 5 (at least as it stands now) so should you have a problem and need to restore you will lose your JB as well. At least with iOS 5.0.1 you will have some of the new notification features and what not. Plus some app updates require iOS 5 and up. I would upgrade but that is my personal opinion.